Faculty
- Raymond and Lynne Ruddon Professor of Cancer Biology and Pharmacology
- Professor of Cell and Developmental Biology; Research Professor, U-M Life Sciences Institute
Pharmacology, School of Medicine; Cell & Developmental Biology, School of Medicine
Research:
Immune cell migration in the context of inflammation and cancer.
Professor of Medicinal Chemistry; Professor of Pharmacology; Professor of Biophysics
Research:
Understanding how the functions of human cytochrome P450 enzymes in drug metabolism and in normal physiology (e.g. steroidogenesis) are controlled by the molecular details of specific P450/ligand interactions. Using X-ray crystallography, NMR, and other structural and biophysical techniques, the goal is to facilitate the design of drugs to improve human health across many different human diseases including cancers.
Research Professor, Life Sciences Institute; Hans W. Vahlteich Professor of Medicinal Chemistry; Professor of Chemistry; Professor of Microbiology and Immunology
Research:
Synthetic chemistry, marine microorganisms, drug discovery
- Director of the Center for Structural Biology, Life Sciences Institute
Margaret J Hunter Collegiate Professor, Life Sciences Institute; Professor of Biological Chemistry
Research:
Protein structure and function using X-ray crystallography
Assistant Professor of Chemistry; Research Associate Professor of Internal Medicine (Adjunct)
Research:
Chemical and cell biology of protein kinases
- Director of the Pharmacokinetics Core, College of Pharmacy
J G Searle Endowed Professor of Pharmaceutical Sciences
Research:
Drug discovery for cancer therapy; Nanotechnology for drug delivery and vaccine delivery; Pharmacokinetics and drug optimization
Professor of Biological Chemistry, Medical School
Research:
Chemical and structural biology of protein posttranslational modifications
Francis S. Collins Collegiate Professor of Chemistry, Biophysics & Biological Chemistry; Founding Co-Director, Center for RNA Biomedicine; Founding Director, Single Molecule Analysis in Real-Time (SMART) Center
Research:
Structural dynamics and applications of RNA and DNA
- Director, Cancer Drug Discovery Program, Co-Director, Molecular Therapeutics Program, U-M Comprehensive Cancer Center
Warner-Lambert/Parke-Davis Professor of Medicine; Professor Internal Medicine; Professor of Pharmacology; Professor of Medicinal Chemistry
Research:
Drug design, synthesis, apoptosis, epigenetics, protein-protein interaction, new computational methods for protein-drug interaction
Research Associate Professor, Life Sciences Institute; Associate Professor of Chemistry
Research:
Optogenetic tools, protein engineering, directed evolution, neuroscience
- Associate Director for Basic Science Research, U-M Comprehensive Cancer Center
Research Professor, Life Sciences Institute; E Gifford and Love Barnett Upjohn Professor of Internal Medicine and Oncology
Research:
Transcriptional regulation of proteolytic effectors operative in cancer
Research Assistant Professor, Life Sciences Institute; Assistant Professor of Biomedical Engineering; Assistant Professor of Pharmaceutical Sciences
Research:
Ultrasensitive single-molecule detection technologies; RNA therapeutics
Associate Professor of Biological Chemistry
Research:
Molecular complexes, membrane trafficking, breast cancer