Courses in Chemical Biology
ChemBio 501 - Chemical Biology I
This course will provide a high-level overview on the structure, function and chemistry of biological macromolecules including proteins, nucleic acids and carbohydrates. Topics include protein and nucleic acid folding, energetics of macromolecular interactions (kinetics and thermodynamics) and mechanistic enzymology. Using specific examples from the current literature, each topic will stress how chemists have used molecular level tools and probes to help understand the specific systems under study. The overarching theme in this course will be that structure and function are intimately linked.
ChemBio 502 - Chemical Biology II
This course is a continuation of ChemBio 501. The basic concepts obtained in ChemBio 501 will be applied to and demonstrated in three broad areas of interest to both chemists and biologists. The first topic will discuss combinatorial methods including SELEX and gene shuffling, combinatorial organic synthesis, high throughput screening and chemical genetics. The second topic will focus on signal transduction, emphasizing general concepts (at the molecular level) and how small molecules have been used to probe and modulate signal transduction pathways. The final topic will cover protein translation, stressing mechanistic aspects of protein synthesis and folding in vivo.
ChemBio 504 - Protein-protein Interactions in Human Disease
This course is intended for graduate students and advanced undergraduates who are interested in protein-protein interactions (PPIs). Topics will be introduced using modern case studies and examples from the literature, taught by experts in the field. Grades will be determined using three written examinations and an oral presentation. The goal of this course is to provide interested students with a comprehensive introduction to PPIs, with an emphasis on their chemical biology and their roles as emerging drug targets. Students will be equipped to think about next-generation ways of exploring PPIs.
ChemBio 599 - Chemical Biology Research Rotation
This course consists of practical hands-on experience in a faculty member's lab. Students receive training in research methods and techniques necessary for the successful conduct of dissertation research as curriculum changes require.
ChemBio 601 - Critical Analysis in Chemical Biology I
In this course, students will read and dissect papers from the current literature. The specific papers will be selected at the discretion of the instructor; however, the topics to be emphasized in the papers will loosely parallel and complement the topics covered in ChemBio 501. This course is available to Chemical Biology students only.
ChemBio 602 - Critical Analysis in Chemical Biology II
In this course, students will read and dissect papers from the current literature. The specific papers will be selected at the discretion of the instructor; however, the topics to be emphasized in the papers will loosely parallel and complement the topics covered in ChemBio 502. This course is available to Chemical Biology students only.
ChemBio 990 - Pre-Candidate Dissertation Research
ChemBio 995 - Candidate Dissertation Research