Faculty


Stephen Weiss

E. Gifford and Love Barnett Upjohn Professor of Internal Medicine and Oncology, Department of Internal Medicine; Research Professor, Life Sciences Institute

M.D., Ohio State University College of Medicine

Research Focus: Transcriptional regulation of proteolytic effectors operative in cancer​

Phone: 734.764.0030
E-mail: sjweiss@umich.edu

Normal as well as neoplastic cell populations remodel the extracellular matrix by regulating the expression of complex gene programs that control cell motility, proteolytic activity, proliferation and morphogenesis. However, the identity of the upstream and downstream gene products that regulate these activities in normal or pathologic states remain unclear, especially within the context of the 3-dimensional matrix. Current efforts focus on identifying the regulation of transcription factors that control epithelial-mesenchymal transitions in carcinomatous states as well as the genetic programs that guide morphogenesis.

 

 

Awards

2009 University of Michigan Distinguished Faculty Award

 

Representative Publications

  1. Ni, T., Li, X-Y, An, T., Fu, R., Rowe, R.G., Lin, Y., Scherer, A., Feinberg, T., Zheng, X., Lu, N., Guo, Q-L, Liu, X.S., Wu, Z-Q and S.J. Weiss. Snail1-Dependent p53 Repression Regulates Expansion and Activity of Tumor-Initiating Cells in Breast Cancer.  Nature Cell Biology, In Press, 2016.

  2. Tang, Y., Feinberg, T., Keller, E.T., Li, X-Y., and S.J. Weiss. Snail1/Slug-YAP/TAZ Complexes Control Skeletal Stem Cell Self-Renewal and Differentiation. Nature Cell Biology, 2016, ​18:917-29.

  3. Dudley, D.T., Li, X.Y., Hu, C.Y., Kleer, C., Willis, A.L. and S.J. Weiss.  A 3-D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies. Proceedings of the National Academy of Sciences, USA, 2014, 111:14882-7.

  4. Tang, Y., Rowe, R.G., Botvinick, E.L., Kurup, A., Putnam, A.J., Seiki, M., Weaver, V.M., Keller, E.T., Goldstein, S.A., Begun, D., Dai, J., Saunders, T.L. and S.J. Weiss.  Control of mesenchymal stem cell commitment by an MT1-MMP/YAP/TAZ mechanotransduction axis. Developmental Cell, 2013, 25:402-416

  5. Shimizu-Hirota, R., Xiong, W., Baxter, B.T., Kunkel, S.L., Maillard, I., Chen, X.-Y., Sabeh, F., Liu, R., Li, X.-Y., and S.J. Weiss.  MT1-MMP-dependent regulation of a PI3Kδ-nucleosome remodeling axis controls macrophage immune function. Genes & Development, 2012, 26:395-413.

 

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