Associate Professor of Biological Chemistry; Research Associate Professor of the Life Sciences Institute
Ph.D.,European Molecular Biology Laboratory in Heidelberg, Germany
Postdoctoral Fellow, Harvard Medical School, Boston, MA
Research Focus: Structural studies of chromatin modifying complexes, Structural studies of signaling cell surface receptors.
The Skiniotis Lab is interested in the 3D visualization of dynamic macromolecular assemblies and the delineation of mechanistic aspects of their operation by applying electron cryo-microscopy (cryo-EM).
We are currently exploring the structural space in two biological areas:
Signaling cell surface receptors
We investigate the structural biology of cytokine receptors and G protein coupled receptor (GPCR) complexes—which constitute the main conduit for information transfer between cells and their environment—in order to reveal the various mechanisms involved in transmembrane signal instigation. By establishing the structural framework of signal transduction we aim to identify novel therapeutic strategies.
Type I polyketide synthases (PKSs) produce a vast array of natural compounds that have antimicrobial, antifungal, antiviral, anticancer, and immunosuppressant activities and form the basis for nearly a third of all pharmaceuticals. We study the structure and dynamics of PKSs to understand how these remarkable enzyme factories work, and to set the stage for bioengineering the production of new medicines.
Skiniotis Research Group
Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK¤, Skiniotis G¤, Lefkowitz RJ¤. Visualization of arrestin recruitment by a G Protein-Coupled Receptor. Nature, DOI 10.1038/nature13430, Epub 2014 June 22.
Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL & Skiniotis G. Structure of a modular polyketide synthase. Nature 2014 Jun 26;510(7506):512-7.
Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL & Skiniotis G. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature 2014 Jun 26;510(7506):560.
Mancour LV, Daghestani HN, Dutta S, Westfield GH, Schilling J, Oleskie AN, Herbstman JF, Skiniotis G. Ligand-Induced Architecture of the Leptin Receptor Signaling Complex. Mol Cell 2012 Nov 30;48(4):655-61. PMCID: PMC3513567.