Ryan Bailey

Robert A. Gregg Professor of Chemistry

Ph.D., Northwestern University
Postdoctoral Fellow, California Institute of Technology and Institute for Systems Biology

Research Focus: Macromolecular Structure and Function; Cancer Chemical Biology

Phone: 734.764.1438
E-mail: ryancb@umich.edu

Biology is continuously advanced by improvements in measurement technologies, experiencing paradigm shifts due to the deeper levels to which scientists can peer into a system. Armed with the fruits of the genomic and proteomic revolutions, biomedicine is now primed for technologies that integrate multiparameter gene and protein profiling and are applicable within the clinical setting. By combining traditional chemical and biological insight with cutting-edge concepts from materials science, physics, and engineering, our group brings an interdisciplinary approach to developing new tools to tackle longstanding, refractory problems in the biomolecular sciences—technologies that will enable fundamental biological discovery, and in some applications, expedite the transfer of biomolecular insight to the hands of the physician where it can directly impact patient care.

Motivated by practical challenges associated with performing multiparameter biological analysis, our group is developing several powerful analysis tools that will be applicable in clinical settings and beyond. Our goal is to facilitate personalized diagnosis and individualized treatment by providing a more detailed picture of the biomolecular signatures of disease from a single patient. On account of their simplicity, scalability, and molecular generality, these tools also have broad applicability to many aspects of clinical and pharmaceutical research as well as fundamental biological studies.

Bailey Research Group



2015 Finalist, Innovation Transfer Award, Champaign County Economic Development Corporation
2015 Pittsburgh Conference Achievement Award, Society for Analytical Chemists of Pittsburgh
2014-2015 Defense Science Study Group, Institute for Defense Analysis/DARPA
2013 Arthur F. Findeis Award for Achievements by a Young Analytical Scientist, Division of Analytical Chemistry, American Chemical Society
2012-2017 Alumni Research Scholar
2012 Named to MIT Technology Review’s TR35: 35 Top Innovators under 35
Helen Corley Petit Scholar


Representative Publications

  1. Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays, J.H. Wade, A.T. Alsop, N.R. Vertin, H. Yang, M.D. Johnson, R.C. Bailey, ACS Central Science, 2015, 1(7), 374-382 DOI: 10.1021/acscentsci.5b00250

  2. Bioanalytical chemistry: Eavesdropping on interactions, E. Valera, R.C. Bailey, Nature Chemistry, 2015, 7, 767-779 DOI: 10.1038/nchem.2355

  3. Development and validation of an immunosensor for monocyte chemotactic protein 1 using a silicon photonic microring resonator biosensing platform, E. Valera, W.W. Shia, R.C. Bailey, Clinical Biochemistry, 2015, In Press DOI: 10.1016/j.clinbiochem.2015.09.001

  4. A tunable, photoreactive hydrogel system to probe synergies between mechanical and biomolecular cues on adipose-derived mesenchymal stem cell differentiation, J.M. Banks, B.A. Harley, R.C. Bailey, ACS Biomaterials Science & Engineering, 2015, 1(8), 718-725 DOI: 10.1021/acsbiomaterials.5b00196

  5. Magnetically-actuated, bead-enhanced silicon photonic immunosensor, E. Valera, M. S. McClellan, R.C. Bailey, Analytical Methods, 2015, 7, 8539 - 8544 DOI: 10.1039/C5AY01477H